Transforming Proteins And Genes Into Drugs

The study and manipulation of life forms on the molecular level continues to set the pace in modern science and medicine. Biotechnology and Biopharmaceuticals represents a unique, textual combination of these two dynamic disciplines, focusing on the role biotechnology plays in the discovery and development of therapeutic drugs. The first of the book's three sections focuses on the process of transforming a macromolecule into a therapeutic agent; the second provides a brief overview of each class of macromolecule with respect to physiological role and clinical application. The second section also provides additional detail for each FDA approved biopharmaceutical. The final section looks to new advances that will enhance our ability to develop new macromolecules into effective biopharmaceuticals. Biotechnology and Biopharmaceuticals also:

• Presents the first-ever effort to provide insight into how biologic and recombinant molecules are developed from a concept to a therapeutic product
• Strives to provide readers with a dynamic view of the science and business aspects of developing biopharmaceuticals
• Describes the key differences in the discovery and development of classical, small-molecule drugs and high-molecular-weight biopharmaceuticals
• Includes information about indications, dosage, clinical pharmacology, toxicology, and therapeutic response
• Offers discussion of cell and gene therapeutics, and genomics/proteomics for drug discovery
• Provides an outline and content suitable for the development of courses in pharmaceutical biotechnology and biopharmaceutics

Biotechnology and Biopharmaceuticals provides an ideal resource for graduate students and undergraduates in colleges of pharmacy and health sciences, for pharmaceutical and biomedical scientists in academia and industry, and for clinical pharmacists and medical center--based clinicians.