Toward a CO2-neutral biotechnology: itaconate production using CO2 derived co-substrates

Given the persistent growth in demand for food, energy, and chemicals in the coming decades, a shift from fossil-based raw materials to sustainable alternatives is required. Using renewable carbon sources will allow a future that is independent of fossil carbon. Itaconate functions as a bio-based building block with many applications. This work focused on metabolic engineering and bioprocess optimization strategies to establish a sustainable Ustilaginaceae itaconate production using CO2-derived co-substrates.