Three Models of Huntington's Disease di Aysha S. Raza edito da LAP Lambert Acad. Publ.
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Three Models of Huntington's Disease

The Neuropathological Investigations of Transgenic Murine Models of Disease

EAN:

9783838328843

ISBN:

3838328841

Pagine:
304
Formato:
Paperback
Lingua:
Tedesco
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Descrizione Three Models of Huntington's Disease

Huntington''s disease (HD) is a purely genetic neurodegenerative disorder affecting approximately 1 in 10,000 people. It is most commonly associated with excessive involuntary movement, or chorea, combined with varying degrees of other motor, psychiatric and cognitive disturbances. Identification of the mutation in the HD gene prompted the generation of several transgenic mouse models. HD is but one of a family of at least 9 triplet repeat disorders, all of which exhibit protein aggregation by a similar mechanism. The understanding of one disease is therefore of importance to the understanding of them all. This work aims to be a comprehensive comparative study of three very different mouse models of HD elucidating the pathological changes that precede and accompany the disease process.

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