Theoretical & Experimental Investigation of  Protein-Drug Interactions di Selimcan Azizoglu edito da LAP Lambert Academic Publishing
Alta reperibilità

Theoretical & Experimental Investigation of Protein-Drug Interactions

via Surface Plasmon Resonance (SPR)

EAN:

9783847306276

ISBN:

3847306278

Pagine:
112
Formato:
Paperback
Lingua:
Tedesco
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Descrizione Theoretical & Experimental Investigation of Protein-Drug Interactions

In this study, interaction of small molecular weight drug compounds with proteins has been characterized. The binding constants of interactions were first theoretically calculated using molecular docking simulations. Next, these interactions were experimentally investigated via Surface Plasmon Resonance (SPR). The theoretical binding constants, KD, predicted from theoretical calculations have been compared with the experimental values obtained from SPR. As a model protein, Escherichia coli (E.coli) DNA photolyase was used due to its known crystal structure. Among the eight drugs analyzed, theoretical and experimental values have shown similar binding affinities between selected drug and protein pairs. The results obtained in this study may be significant to characterize the unknown interactions of existing drugs with various proteins.

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