Synthesis and Evaluation of anti-TB and Pro-apoptoticQuinones

Tuberculosis and Cancer are among the mostdevastating and therapeutically challenging diseases.The development of muti-drug resistance in TB causingbacteria, Mycobacterium tuberculosis and cancerouscells has prompted the search for effective novelcompounds. This book focuses on the synthesis and theevaluation of different analogues of diospyrin, aproven anti-TB and anti-cancer agent. A number ofnovel binaphthoquinone and naphthoquinone-naphthalenebiaryl compounds were synthesized by using Suzukimethodology.Several analogues were evaluated for their biologicalactivity against fast growing bacteria viz., M.smegmatis and M. aurum and against a clinical strainof M. tuberculosis. Four novel quinones were alsoevaluated for their ability to induce apoptosis inthree cancer cell lines viz., HeLa, MCF7, MG63 andone normal cell line i.e. CHO by using APOpercentage,DNA fragmentation and Cell cycle assays. Thispreliminary investigation could provoke an interestin scientific community to synthesize otherstructurally modified quinonoids in order to developand establish them as potent drugs againstmycobacterium and cancer.