Small Nucleolar RNA Snora53

Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. The snoRNA ACA53 belongs to the H/ACA family of pseudouridylation guide snoRNAs. This H/ACA box RNA was cloned by Kiss et al. (2004) from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. It has no identified target RNA. RNA residues targeted for pseudouridylation by this molecule have not been identified. Small nucleolar RNAs (snoRNAs) are a class of small RNA molecules that primarily guide chemical modifications of other RNAs, mainly ribosomal RNAs, transfer RNAs and small nuclear RNAs. There are two main classes of snoRNA, the C/D box snoRNAs which are associated with methylation, and the H/ACA box snoRNAs which are associated with pseudouridylation. snoRNAs are commonly referred to as guide RNAs but should not be confused with the guide RNAs that direct RNA editing in trypanosomes.