Role of neuronal IGF-1R signaling in Alzheimer's disease di Moritz M. Hettich edito da Südwestdeutscher Verlag für Hochschulschriften AG  Co. KG
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Role of neuronal IGF-1R signaling in Alzheimer's disease

Involvement in development and progression

EAN:

9783838128788

ISBN:

3838128788

Pagine:
116
Formato:
Paperback
Lingua:
Tedesco
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Descrizione Role of neuronal IGF-1R signaling in Alzheimer's disease

Brains from patients with AD reveal a markedly down regulaton of IGF-1R expression and these changes progress with severity of neurodegeneration. To investigate the role of neuronal IGF-1R signaling in AD a neuron-specific IGF-1R deficient mice were generated and were crossed with mice expressing mutated human APP which was found in a Swedish family with early-onset AD. The offsprings of these mice were analysed. Kaplan-Meier-analysis after 60 weeks of observation revealed that nIGF-1R knockout mice were protected against premature mortality of AD mice and showed reduced A¿ accumulation. In addition A¿ plaque burden in animals with neuronal IGF-1R deletion was also reduced compared to AD animals. Taken together IGF-1R mediated signals influence APP processing leading to reduced A¿ accumulation and amyloid plaque burden. Thus, downregulation of IGF-1R observed in brain of patients suffering from Alzheimer¿s disease is most likely a compensatory phenomenon.

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