Relation between cytokines and diabetic nephropathy

- Diabetes is a very common disease. - Nephropathy is 0ne of a microvascular complication of diabetes. - Cytokines have a critical role in pathogenesis of diabetic nephropathy. - Cytokines such as transforming growth factor beta 1 (TGF beta 1), connective tissue growth factor (CTGF), monocyte chemoattractant protein 1 (MCP 1) and fibronectin (FN)may cause inflammation or fibrosis or both in diabetic nephropathy.