Rasgef Domain

Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. RasGEF domain is domain found in a family of guanine nucleotide exchange factors for Ras-like small GTPases. Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP. The balance between the GTP bound (active) and GDP bound (inactive) states is regulated by the opposite action of proteins activating the GTPase activity and that of proteins which promote the loss of bound GDP and the uptake of fresh GTP. The latter proteins are known as guanine-nucleotide dissociation stimulators (GDSs) (or also as guanine-nucleotide releasing (or exchange) factors (GRFs)).