R-Ras Proteins, TGF-Beta and Cancer di Mete Erdogan edito da LAP Lambert Acad. Publ.
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R-Ras Proteins, TGF-Beta and Cancer

Mechanisms of Interaction Among the R-Ras, TC21 and TGF-Beta Signaling Pathways

EAN:

9783838306643

ISBN:

3838306643

Pagine:
112
Formato:
Paperback
Lingua:
Tedesco
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Descrizione R-Ras Proteins, TGF-Beta and Cancer

During the progression of human cancers, normal cells acquire genetic and epigenetic changes in the signaling pathways that govern their proliferation, resulting in uncontrolled growth and tumor formation. Oncogenic Ras and Transforming Growth Factor-Beta are known to cooperate in promoting malignant transformation, yet the mechanism by which they interact has not been established. Here, we present novel mechanisms through which Transforming Growth Factor-Beta interacts with two Ras-related proteins, R-Ras and TC21, to transform mammary epithelial cells.

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