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Peptidomimetics Protocols
- Editore:
Humana Press Inc.
- Collana:
- Methods in Molecular Medicine
- EAN:
9781617370595
- ISBN:
1617370592
- Pagine:
- 549
- Formato:
- Paperback
- Lingua:
- Inglese
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Descrizione Peptidomimetics Protocols
A state-of-the-art collection of detailed synthetic procedures that lead to a variety of scaffolds, turn mimetics, peptide-bound replacements, and enzyme inhibitors. Topics range from unusual syntheses of amino acids to the use of a variety of linear and heterocyclic scaffolds in place of the peptide backbone. Important chemical procedures and methods include the transient protection of charged peptides as neutral prodrugs for improved blood-brain penetration and the replacement of peptide bonds with heterocyclic rings, olefins and fluoroolefins, and ketomethylenes. Synthetic protocols towards the transition-state mimics and reactive "warheads," applicable in enzyme inhibitors, are also disclosed.
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