Monocyte NADPH Oxidase: Role of Pattern Recognition Receptors di Deena Elsori edito da LAP Lambert Academic Publishing
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Monocyte NADPH Oxidase: Role of Pattern Recognition Receptors

Role Of Pattern Recognition Receptors

EAN:

9783848418138

ISBN:

3848418134

Pagine:
76
Formato:
Paperback
Lingua:
Tedesco
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Descrizione Monocyte NADPH Oxidase: Role of Pattern Recognition Receptors

Activation of the NADPH oxidase enzyme complex results in the production of the oxygen free radical, superoxide anion (O2.-). Superoxide anion is critical for host defense against fungal and bacterial pathogens and efficient immune responses; however, uncontrolled monocyte-derived O2.- may contribute to chronic inflammation and tissue injury. We have previously identified several pathways that regulate the activity of NADPH oxidase in human monocytes; however, the receptor(s) responsible for the activation of NADPH oxidase in primary human monocytes have not yet been determined. This dissertation shows that pattern recognition receptors, namely Dectin-1, is essential for regulating NADPH oxidase activity in Zymosan-activated human monocytes. In addition this book focuses on Dectin-1 downstream signaling and complex formation with intracellular signaling proteins.

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