Molecular properties prediction and synthesis of oxadiazole analogues di Rakesh Sharma, Piush Sharma, Mohamed Jawed Ahsan edito da LAP Lambert Academic Publishing
Alta reperibilità

Molecular properties prediction and synthesis of oxadiazole analogues

Molecular properties prediction and synthesis of oxadiazole analogues as antimicrobial agents

EAN:

9783659758638

ISBN:

3659758639

Pagine:
68
Formato:
Paperback
Lingua:
Tedesco
Acquistabile con o la

Descrizione Molecular properties prediction and synthesis of oxadiazole analogues

A series of 11 oxadiazole analogues were subjected to molecular properties prediction and drug likeness by Molinspiration and MolSoft software, lipophilicity and solubility parameters using ALOGPS 2.1 program. The compounds followed the Lipinski "Rule of five" were synthesized for antimicrobial screening as oral bioavailable drugs/leads. Further the structure of the synthesized compounds was confirmed by spectral analyses (IR, NMR and mass) and the compounds (4a-k) were evaluated for antibacterial and antifungal activities as per the standard protocol. N-(2-Methylphenyl)-5-(4-chlorophenyl)-1,3,4-oxadiazol-2-amine, 4c was found to have maximum antibacterial activity while N-(2-methylphenyl)-5-(4-hydroxyphenyl)-1,3,4-oxadiazol-2-amine, 4d showed maximum antifungal activity.

Spedizione gratuita
€ 42.42
o 3 rate da € 14.14 senza interessi con
Disponibile in 10-12 giorni
servizio Prenota Ritiri su libro Molecular properties prediction and synthesis of oxadiazole analogues
Prenota e ritira
Scegli il punto di consegna e ritira quando vuoi

Recensioni degli utenti

e condividi la tua opinione con gli altri utenti