Long-lasting stress-induced changes in neuronalalternative splicing
- Editore:
VDM Verlag
- EAN:
9783639147162
- ISBN:
3639147162
- Pagine:
- 100
- Formato:
- Paperback
- Lingua:
- Tedesco
Descrizione Long-lasting stress-induced changes in neuronalalternative splicing
Ample information suggests multileveled relationshipsbetween long-term psychological stress responses andalternative splicing - the process which yieldsdifferent mRNAs from the same gene. However, thenature of these relationships remains unclear. EranMeshorer studied the stress-induced changes inalternative splicing at Hermona Soreq's lab and shedlight on the molecular pathways that lead to suchresponses. Meshorer focused on a particular mRNA -acetylcholinesterase (AChE), which isneuronally-expressed, stress-responsive, and yieldsalternatively spliced products, thus serving as anadequate model for this purpose. The book begins withan introduction covering the general areas of stressresponses, their long-term consequences, themechanism of splicing and alternative splicing,neuritic translocation of mRNAs and highlights theAChE gene and its protein products as putativemediators of such long-term consequences. The resultssection depicts 3 works describing 3' and 5'alternative splicing of AChE and a potential mediatorof the stress-induced responses. Finally, the bookends with a discussion on the consequences of suchresponses, linking stress responses with aging.
