Lats2

Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Serine/threonine-protein kinase LATS2 is an enzyme that in humans is encoded by the LATS2 gene.This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage.