INTERACTIONS OF FLAVONES AND RELATED COMPOUNDS WITHNUCLEIC ACIDS
An approach to study interactions betweennatural compounds with nucleic acids and synthesis offlavonoid derivatives
- Editore:
VDM Verlag
- EAN:
9783639157673
- ISBN:
3639157672
- Pagine:
- 260
- Formato:
- Paperback
- Lingua:
- Tedesco
Descrizione INTERACTIONS OF FLAVONES AND RELATED COMPOUNDS WITHNUCLEIC ACIDS
Across the world, different diseases have beentreated with herbal extracts, based on common andempiric knowledge. The process of identification ofthe active compounds and their synthesis,optimisation and development for new drug candidatesappropriate for clinical use is described asMedicinal Chemistry; a discipline merging chemistryand pharmacology. This monograph describes a group of activeingredients from herbal medicines, as a foundationfor the development of new anticancer drugs.Interactions between with genomic DNA, syntheticpolynucleotides and higher order DNA isoforms (tripleand quadruple helical forms) have been studied.Rational drug design has been also employed duringthis project to elucidate the mode of binding andnovel compounds have been synthesized to provideprecise structure-activity related studies resultingin a second generation of chemotherapeutic anticanceragents with improved properties. This book provides information and protocols forstudying drug-DNA interactions using spectroscopicaland biological techniques; synthesis of flavonoidsand the principles to explore the use of QuantitativeStructure Activity Relationship Studies.
