Integrated View of Reactive Oxygen Species, Oxidative Stress in Ageing

1. Introduction ¿ Types of reactive oxygen species (ROS) ¿ Sources ¿ Structure ¿ Mechanism of ROS generation ¿ p53,oxidative stress and ROS. 2. Oxidative stress and free radical damage ¿ Oxidative lipid damage ¿ Oxidative DNA damage ¿ Oxidative protein damage ¿ Role of ROS in cell signaling ¿ Aberrant regulation of redox-sensitive signal pathway ¿ Molecular mechanism of age-related diseases. 3. Antioxidant defense ¿ Antioxidant therapy ¿ Oxidative modification of protein and possible biomarkers. 4. Specific pathways transduced by ROS and ROS-induced apoptosis will provide opportunities to impact both life span, Age related-diseases and design the chemotherapeutics for humans.