Gluten-sensitive Enteropathy Associated Conditions

Gluten-sensitive enteropathy has a wide variety of associated conditions, however the key symptoms are typically restricted to the bowel and associated tissues. These include bowel disorders (diarrhoea, constipation, irritable bowel), eosinophilic gastroenteritis and increase with coeliac disease (CD) severity. With some early onset and a large percentage of late onset disease, other disorders appear prior to the celiac diagnosis or allergic- like responses (IgE or IgA, IgG) markedly increased in GSE many which persist on a strict GF diet, and thus become independent of coeliac disease after triggering. For example autoimmune thyroiditis is a common finding with GSE.However, GSE's association with disease is not limited to common autoimmune diseases, coeliac disease has been found at increased frequency on followup to many autoimmune diseases, some rare. Complex causes of autoimmune diseases often demonstrates only weak association with celiac disease. The frequency of GSE is typically around 0.3 to 1% and lifelong risk of this form of gluten sensitivity increases in age, possibly as high as 2% for people over 60 years of age.