Genes & Cancer: Myc: A Far-Reaching Cancer Gene: Volume 1, Issue 6; June 2010

As one of the first oncogenes identified, Myc has enjoyed an illustrious history. In reflection of 30 years of research and in excess of 20,000 published articles, two major themes emerge. First, the fine-tuned regulation and numerous activities of Myc in normal cells are unparalleled and a beauty to behold. Second, when this regulation is lost, Myc rears its beastly head and takes the role of one of the most prominent and intriguing of oncoproteins. (From Myc: The Beauty and the Beast by Amanda R. Wasylishen and Linda Z. Penn in Genes & Cancer Vol 1 No 6, 2010.)