Formulation Development of Extended Released Rifaximin Micro-particles di Kiran Bhise, Rohan Karanje edito da LAP Lambert Academic Publishing
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Formulation Development of Extended Released Rifaximin Micro-particles

EAN:

9783659418402

ISBN:

3659418404

Pagine:
128
Formato:
Paperback
Lingua:
Tedesco
Acquistabile con la

Descrizione Formulation Development of Extended Released Rifaximin Micro-particles

This book addresses the formulation and process design aspects of extended release micro particles of BCS class IV drug Rifaximin through cyclodextrin complexation and extending the drug release by Eudragit L -100 enteric coating. The concept of surface response methodology was used in the selection of optimized batch that was further evaluated for various parameters. The data supports an improvement in aqueous solubility of BCS class IV drugs through cyclodextrin complexes. The release of such inclusion complexes can be retarded for 8 hrs by enteric coating.

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