Fbxw4

Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. F-box/WD repeat-containing protein 4 is a protein that in humans is encoded by the FBXW4 gene.This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly.