Carboplatin Induced Cytotoxicity

Beside its toxic side effects on vital proliferating tissues of the patient, chemotherapy is still a treatment of choice for certain forms of human malignancy. Though most anti-cancer drugs are known to exert their cell killing effect through various intracellular pathways, including their interference with the DNA replication, many anticancer agents has not, in general, been chosen for therapy after a thorough evaluation of their cytotoxic effect on chromosomes of proliferating body cells. This work has been designed to provide an understanding of the nature and extent of cytotoxicity of a widely used second generation platinated anticancer agent, Carboplatin on bone marrow cells of both non tumor and tumor bearing mice and its possible modulation by three diverse agents viz. Glutathione (chemo-preventive agent), Mitomycin C (anticancer antibiotic) and Amphotericin B (anti-fungal agent). Tumor bearing mice were included in the present program to find out whether tumor load has any influence on bone marrow cytotoxicity of Carboplatin. This book should be especially useful to researchers, oncologists, students and/or anyone else who is interested in pharmacology and toxicology.