Bub1
- Editore:
Betascript Publishing
- EAN:
9786135210798
- ISBN:
6135210793
- Pagine:
- 80
- Formato:
- Paperback
Descrizione Bub1
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Mitotic checkpoint serine/threonine-protein kinase BUB1 also known as BUB1 (budding uninhibited by benzimidazoles 1) is an enzyme that in humans is encoded by the BUB1 gene.Bub1 is a serine/threonine protein kinase first identified in genetic screens of Saccharomyces cerevisiae. The protein is bound to kinetochores and plays a key role in the establishment of the mitotic spindle checkpoint and chromosome congression. The mitotic checkpoint kinase is evolutionary conserved in organisms as diverse as Saccharomyces cerevisiae and humans. Loss-of-function mutations or absence of Bub1 has been reported to result in aneuploidy, chromosomal instability (CIN) and premature senescence.
Inserisci la tua e-mail per essere informato appena il libro sarà disponibile