ASTROGLIOSIS AND CHANNEL FUNCTION

Astrogliosis is a hallmark of central nervous system (CNS) neuroinflammatory disorders such as multiple sclerosis (MS). Astrocytes can play both beneficial and detrimental roles in response to neuroinflammation, thus a detailed understanding of the underlying molecular mechanisms governing astrogliosis might facilitate the development of therapeutic targets. While astrocytes do not express voltage-gated sodium channel (VGSC) Nav1.5 in nonpathological human brain, they exhibit robust upregulation of Navi .5 within acute and chronic MS lesions