Search for Breast Cancer Susceptibility Genes
The Growth Hormone-1 / Insulin-like Growth Factor-1Pathway and its Relationship to Breast Cancer
- Editore:
VDM Verlag
- EAN:
9783639022070
- ISBN:
3639022076
- Pagine:
- 132
- Formato:
- Paperback
- Lingua:
- Tedesco
Descrizione Search for Breast Cancer Susceptibility Genes
Breast Cancer is the most common cancer in Westernwomen and represents 28% of female cancer deaths.During the last decades, research has revealed canceras a complex heterogeneous disease triggered bydynamic changes in the genome. The work in this dissertation summarizes theinvestigation of polymorphisms in the GH1/IGF-1 axisin relation to breast cancer risk by means of theplanning and conducting of case-control studies. Manyfindings were novel and they reflected the complexityof the gene regulation along the GH1/IGF-1 pathway.In summary, the studied polymorphisms were mainlyassociated with a decreased breast cancer risk. Thislead to the suggestion that genetic variants in theGH1/ IGF-1 axis do not increase the mitogenic andantiproliferative features of the pathway, but ratherprotect the cells from proliferation. The studycontributes to the world-wide effort ofidentification of low-penetrance genetic variants,which may be useful tools for prevention, prognosisand planning of individual therapy.
