Strategies for Organic Drug Synthesis and Design

06Die organische Synthese basiert auf dem Einsatz organischer Umwandlungen bei der Herstellung neuer Verbindungen mit mehr oder weniger komplexen Strukturen. Sie hat weitreichende Konsequenzen für die moderne organische Chemie. Dieses Buch bietet eine Auswahl an Syntheseverfahren zur Veranschaulichung der Strategien und organischen Umwandlungen, wie sie zur Herstellung der verschiedenen Strukturklassen von Wirkstoffen benutzt wurden.03Aliphatic and Alicyclic Compounds; Monocyclic Aromatic Compounds; Polycyclic Aromatic Compounds and Their Reduction Products; Steroids: Part 1: Estranes, Gonanes, and Adrostanes; Steroids: Part 2: Progestins and Corticosteroids; Nonsteroid Estrogens and Their Antagonists; Opioid Analgesics; Five Membered Heterocycles; Six Membered Heterocycles; Benzo-Fused Five Membered Heterocycle; Benzo-Fused Six Membered Heterocycles; Heterocycles Fused to Two Benzene Rings; Betelactams; Polycyclic Fused Heterocycles.16All of the breadth and depth of organic drug synthesis-in one resourceThis work offers a clear examination of the synthetic routes followed to prepare a range of compounds with assigned generic names. With drugs selected for the illustrative value of the chemistry used for synthesis, the book illustrates a great varietyof organic transformations and structural classes of compounds.Ideal for anyone learning or working in organic, medicinal, or pharmaceutical chemistry today, Strategies for Organic Drug Synthesis and Design includes: Coverage of carbocyclic and heterocyclic compounds-steroids, opioid analgesics, beta lactam antibiotics, and more Hundreds of reaction flow charts detailing routes used to prepare over 600 compounds Biological rationales for drug classes and actions of individual agents Capsule presentations of basic principles of drug action An extensive chemical reaction index with over 3,000 entries.04From the contents:Prostaglandins, Protease Inhibitors, and Retinoids.Drugs Based on a Substituted Benzene Ring.Indenes, Naphthalenes, and Other Polycyclic Aromatic Compounds.Steroids: Part 1: Estranes, Gonanes, and Androstanes.Steroids: Part 2: Compounds Related to Progesterone and Cortisone.Nonsteroidal Estrogens and Their Antagonists.Opioid Analgesics.Drugs Based on Five-Membered Heterocycles.Drugs Based on Six-Membered Heterocycles.Five-Membered Heterocycles Fused to a Benzene Ring.Six-Membered Heterocycles Fused to a Benzene Ring.Seven-Membered Heterocyclic Rings Fused to Benzene.Heterocycles Fused to Two Benzene Rings.Beta-Lactam Antibiotics.Heterocycles Fused to Other Heterocyclic Rings.Cross Index of Compounds.Indexes.02DANIEL LEDNICER, PhD, is the acclaimed author of several books on drug synthesis and discovery. His career in both the private and public sectors has been devoted to the search for new therapeutic agents. Dr. Lednicer spent two decades at the bench as a chemist at the Upjohn Company. Following that, he served as director of chemical research at Mead Johnson, director of pharmaceutical sciences at Adria Laboratories, and pharmaceutical manager at Analytical Biochemistry Laboratories. Most recently, he was a project officer at the National Cancer Institute.