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Role of Capsaicin in Oxidative Stress and Cancer
- Editore:
Springer-Verlag GmbH
- Collana:
- Diet and Cancer
- EAN:
9789400763166
- ISBN:
9400763166
- Pagine:
- 178
- Formato:
- Hardback
- Lingua:
- Inglese
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Descrizione Role of Capsaicin in Oxidative Stress and Cancer
This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.
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