Evolution, Modularity, and Dynamics of Gene Regulatory Networks
- Editore:
VDM Verlag Dr. Müller e.K.
- EAN:
9783836494465
- ISBN:
3836494469
- Pagine:
- 140
- Formato:
- Paperback
- Lingua:
- Tedesco
Descrizione Evolution, Modularity, and Dynamics of Gene Regulatory Networks
This book studies the interplay between gene regulatory networks, phenotype and evolution via a combination of concept, theory and experiment. At the conceptual level, the author demonstrates that genes in regulatory networks group into surprisingly well-defined evolutionary modules with distinctive rates of evolution and conserved patterns of gene expression. At the theoretical level, the author develops a a novel probabilistic model for estimating the phylogeny of a pathway. Finally, the author analyses experimental data to reveal that genes sharing expression patterns (transcriptional modules) are not always evolutionarily conserved, but that genes sharing phylogenetic patterns (evolutionary modules) are typically co-expressed. These comparative approaches begin the attempt towards a system-level understanding of how evolution is linked to the design and dynamics of regulatory networks, and how these networks function across timescales from microseconds to eons.
